2019年11月至今：中科院上海有机化学研究所生物与化学交叉研究中心 研究员、课题组长

2016年11月-2019年11月： 哈佛大学医学院 博士后

2016年6月-2016年10月： 中科院上海有机化学研究所 助理研究员

2011年9月-2016年06月： 中科院上海有机化学研究所 博士

2007年9月-2011年06月： 浙江大学 学士

细胞生物学和化学生物学；

细胞死亡、炎症和内稳态失调的调控机制以及在人类疾病中的作用；

衰老和神经退行性疾病的调控机理；

蛋白翻译后修饰及其生理病理功能

2011   浙江大学竺可桢特优毕业生

2012-2014   中国科学院大学“三好学生”

2015    冷泉港亚洲奖学金

1. Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, Mifflin L, Pan L, Amin P, Li W, Shan B, Naito M, Geng J, Meng H, Li Y, Pan H, Aron L, Adiconis X, Levin J, Yankner B, Yuan J. TBK1 suppresses RIPK1-driven apoptosis and inflammation during development and in aging. Cell. 2018, 174(6):1477.

 

2. Xu D, Liu J, Fu T, Shan B, Qian L, Pan L, Yuan J. USP25 regulates Wnt signaling by controlling the stability of tankyrases. Genes Dev. 2017, 31(10):1024.

 

3. Xu D, Shan B, Sun H, Xiao J, Zhu K, Xie X, Li X, Liang W, Lu X, Qian L, Yuan J. USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1. Genes Dev. 2016. (15):1718.

 

4. Xu D, Shan B, Lee BH, Zhu K, Zhang T, Sun H, Liu M, Shi L, Liang W, Qian L, Xiao J, Wang L, Pan L, Finley D, Yuan J. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system. Elife. 2015, 4:e10510.

 

5. Xu D, Zhang T, Xiao J, Zhu K, Wei R, Wu Z, Meng H, Li Y, Yuan J. Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon. Autophagy. 2015, 11(4):617.

 

6. Xu D, Lv C, Chen W. Palladium-catalyzed double arylations of terminal olefins in acetic acid. Tetrahedron, 2012, 68(5):1466.

 

7. Naito M, Xu D, Amin P, Lee J, Wang H, Li W, Kelliher M, Pasparakis M, Yuan J. Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke. PNAS. 2020, 117(9):4959.

 

8. Zhu K, Liang W, Ma Z, Xu D, Cao S, Lu X, Liu N, Shan B, Qian L, Yuan J. Necroptosis promotescell-autonomous activation of proinflammatory cytokine gene expression. Cell Death Dis. 2018, 9(5):500.

 

9. Li F, Xu D, Wang Y, Zhou Z, Liu J, Hu S, Gong Y, Yuan J, Pan L. Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated

phosphorylation. Autophagy. 2018, 14(1):66.

 

10. Geng J, Ito Y, Shi L, Amin P, Chu J, Ouchida AT, Mookhtiar AK, Zhao H, Xu D, Shan B, Najafov A, Gao G, Akira S, Yuan J. Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis. Nat Commun. 2017, 8(1):359.

 

11. Zhang T, Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, Xiao J, Jin Z, Peng T, Gao Y, Cai Y, Qi C, Zhang Q, Sun A, Lipinski M, Zhu H, Xiong Y, Pandolfi PP, Li H, Yu Q, Yuan J. G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L. Elife. 2015, 4:e06734.

 

12. Xiao J, Zhang T, Xu D, Wang H, Cai Y, Jin T, Liu M, Jin M, Wu K, Yuan J. FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation. Genes Dev. 2015, 29(2):184.

 

13. Liu B, Zhang Y, Xu D, Chen W. Facile synthesis of metal N-heterocyclic carbene complexes. Chem Commun, 2011, 47(10):2883.

 

14. Gu S, Xu D, Chen W. Heterobimetallic complexes containing an N-heterocyclic carbene based multidentate ligand and catalyzed tandem click/Sonogashira reactions. Dalton Trans. 2011, 40(7):1576.