陈以昀--生命过程小分子调控全国重点实验室

研究员

陈以昀/男

学　　历：博士
职　　称：研究员
电　　话：(86)21-54925508
电子邮件：yiyunchen@sioc.ac.cn
专家类别：研究员
通讯地址：上海市零陵路345号
课题组网页：http://yiyunchen.sioc.ac.cn/

简介

陈以昀博士，现任中国科学院上海有机化学研究所生命过程小分子调控全国重点实验室研究员、课题组长，同时兼任上海科技大学物质学院教授。他于北京大学获得化学学士学位，在普林斯顿大学取得有机化学博士学位，并在哈佛大学和霍华德休斯医学研究所进行博士后研究。陈博士的研究兴趣集中于生物相容光化学领域，致力于有机光化学与光化学生物学的研究。

研究方向

生物相容光化学：有机光化学，光化学生物学

获奖及荣誉

中国科学院大学优秀授课教师，中国，2022
药明康德生命化学研究奖，中国，2021
上海市科技系统青年五四奖章，中国，2018
Thieme化学期刊奖，德国，2018
中国光化学优秀青年科学家奖，中国，2017
普林斯顿大学百时美施贵宝研究生合成化学奖，美国，2005

承担科研项目情况

国家自然科学基金委员会重点项目，上海市优秀学术带头人计划，中国科学院创新交叉团队，国家自然科学基金委员会优秀青年科学基金项目，上海市浦江人才计划项目

代表论著

1. Zou, P.¹; Fu, D.¹; Wang, H.¹; Sun, R.; Lan, Y.*; Chen, Y.* Photochemical 1,3-Boronate Rearrangement Enables Three-Component N-Alkylation for α-Tertiary Hydroxybenzylamine Synthesis. Nat. Commun. 2024, 15, 10234.

2. Dong, X.¹; Shao, Y.¹; Liu, Z.; Huang, X.; Xue, X.*; Chen, Y.* Radical 6-Endo Addition Enables Pyridine Synthesis under Metal-Free Conditions. Angew. Chem., Int. Ed. 2024, 63, e202410297.

3. Zeng, K.¹; Jiao, Z.¹; Jiang, Q.; He, R.; Zhang, Y.; Li, W.*; Xu, T.*; Chen, Y.* Genetically Encoded Photocatalysis Enables Spatially Restricted Optochemical Modulation of Neurons in Live Mice. ACS Cent. Sci. 2024, 10, 1, 163–175.

4. Hao, K.¹; Li, D.¹; Fu, D.; Zou, P.; Xie, S.; Lan, Y.*; Chen, Y.* Metal-Free 1,3-Boronate Rearrangement to Ketones Driven by Visible Light. Angew. Chem., Int. Ed. 2024, 63, e202316481.

5. Liu, D.¹; Yang, K.¹; Fang, D.¹; Li, S.; Lan, Y.*; Chen, Y.* Formyl Radical Generation from α-Chloro N-Methoxyphthalimides Enables Selective Aldehyde Synthesis. Angew. Chem., Int. Ed. 2023, 62, e202213686.

6.Zhang, Y.¹; Han, L.¹; Tian, X.; Peng, C.;Chen, Y.*Ligand-Directed Caging Enables the Control of Endogenous DNA Alkyltransferase Activity with Light inside Live Cells.Angew. Chem., Int. Ed.2022, 61, e202115472.

7.Wang, H.¹; Zhang, Y.¹; Zeng, K.¹; Qiang, J.¹; Cao, Y.; Li, Y.; Fang, Y.; Zhang, Y.*;Chen, Y.*Selective Mitochondrial Protein Labeling Enabled by Biocompatible Photocatalytic Reactions inside Live Cells.JACS Au2021, 1, 1066−1075.

8.Xie, S.; Li, D.; Huang, H.; Zhang, F.;Chen, Y.*Intermolecular Radical Addition to Ketoacids Enabled by Boron Activation.J. Am. Chem. Soc.2019, 141, 16237−16242.

9.Wang, H; Li, W.; Zeng, K.; Wu, Y.; Zhang, Y.; Xu, T.*;Chen, Y.*Photocatalysis Enables Visible Light Uncaging of Bioactive Molecules in Live Cells.Angew. Chem., Int. Ed.2019, 58, 561−565.

10. Zhang, J.; Li, Y.; Xu, R.; Chen, Y.* Donor-Acceptor Complex Enables Alkoxyl Radical Generation for Metal-Free C(sp³)-C(sp³) Cleavage and Allylation/Alkenylation. Angew. Chem., Int. Ed. 2017, 56, 12619−12623.

11. Jia, K.; Pan, Y.; Chen, Y.* Selective Carbonyl-C(sp³) Bond Cleavage to Construct Ynamides, Ynoates, and Ynones by Photoredox Catalysis. Angew. Chem., Int. Ed. 2017, 56, 2478–2481.

12. Qi, L.; Chen, Y.* Polarity-Reversed Allylations of Aldehydes, Ketones, and Imines Enabled by Hantzsch Ester in Photoredox Catalysis. Angew. Chem., Int. Ed. 2016, 55, 13312−13315.

13. Jia, K.; Zhang, F.; Huang, H.; Chen, Y.* Visible-Light-Induced Alkoxyl Radical Generation Enables Selective C(sp³)-C(sp³) Bond Cleavage and Functionalizations. J. Am. Chem. Soc. 2016, 138, 1514−1517.

14. Zhang, J.; Li, Y.; Zhang, F.; Hu, C.; Chen, Y.* Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp³)-H Functionalization under Mild Reaction Conditions. Angew. Chem., Int. Ed. 2016, 55, 1872−1875.

15. Huang, H.¹; Zhang, G.¹; Chen, Y.* Dual Hypervalent Iodine(III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions. Angew. Chem., Int. Ed. 2015, 54, 7872−7876.

16. Huang, H.; Jia, K.; Chen, Y.* Hypervalent Iodine Reagents Enable Chemoselective Deboronative/Decarboxylative Alkenylation by Photoredox Catalysis. Angew. Chem., Int. Ed. 2015, 54, 1881−1884.

17.Huang, H.; Zhang, G.; Gong, L.; Zhang, S.;Chen, Y.*, Visible-Light-Induced Chemoselective Deboronative Alkynylation under Biomolecule-Compatible Conditions. J. Am. Chem. Soc.2014, 136, 2280−2283.

18. Dumelin, C.; Chen, Y.; Leconte, A. M.; Chen, Y. G.; Liu, D. R.*, Discovery and Biological Characterization of Geranylated RNA in Bacteria. Nat. Chem. Bio. 2012, 8, 913−919.

19. Chen, Y.; Kamlet, A. S.; Steinman, J. B.; Liu, D. R.*, A Biomolecule-Compatible Visible-Light-Induced Azide Reduction from a DNA-Encoded Reaction-Discovery System. Nature Chem. 2011, 3, 146−153.

20. Chen, Y.; Ho, D. M.; Lee, C.*, Ruthenium-Catalyzed Hydrative Cyclization of 1,5-Enynes. J. Am. Chem. Soc. 2005, 127, 12184−12185.