主要从事靶向递药系统和生物活性载体材料研究。研究内容主要包括：1）利用协同递送策略，发展新型纳米载药系统，主动调控肿瘤免疫微环境，抗肿瘤转移和复发；2）通过分子设计，构建肿瘤微环境响应纳米载药系统克服肿瘤组织和细胞生理屏障，提高药物转运效率，显著改善肿瘤化疗和RNA干扰治疗效果；3）从分子、细胞和组织层面揭示纳米载药系统抗肿瘤耐药和转移的关键作用机制。主持基金委“优青”基金、面上项目和科技部“973”课题等多项国家级科研项目。发表SCI论文100余篇，包括Science Immunology, Nature Communication和Advanced Materials等期刊。申报中国发明专利11项，授权5项，新药技术转让1项。担任Mater Exp 副主编和多个国内外期刊编委，在重要学术会议作邀请或分会报告40余次。
课题组常年招聘免疫学、药物化学和生物材料相关专业博士后，欢迎来信咨询。
工作经历
2018.10-现在 课题组长，中国科学院上海药物研究所
2016.10-现在 研究员，中国科学院上海药物研究所
2012.05-2016.09 中国科学院上海药物研究所，副研究员
2011.02-2012.04 日本东北大学，博士后(助手)
2009.02-2011.01 美国德州大学西南医学中心癌症中心，博士后
2007.02-2009.01 德国慕尼黑大学药学系，博士后
社会任职
1. 2018.10-现在，The Journal of Gene Medicine，编委
2. 2017.08-现在，Current Applied Polymer Science (Bentham Science)，编委
3. 2017.01-现在，《药学学报》 青年编委
4. 2017.10-现在，中国抗癌协会纳米肿瘤学青年委员会，副主任委员
5. 2017.08-现在，中国医药生物技术协会纳米生物技术分会，常务委员
6. 2017.09-现在，中国药学会，高级会员
7. 2016.10-现在，中国毒理学会纳米毒理学青年委员会，委员
1. 新型药物递释系统和药用功能辅料开发
2. 智能纳米诊疗系统研究
2017年 科技部中青年科技创新领军人才
2017年 中国药学会-赛诺菲青年生物药物奖
2016年 国家基金委优秀青年基金
2016年 科技部重点领域创新团队骨干成员
2015年 国家自然科学基金委创新研究群体成员
2015年 中国药学会科学技术奖一等奖（排名第四）
2014年 中国药学会-中恒青年药剂学奖
2013年 赛诺菲-上海生科院优秀青年人才奖
2013年 中国科学院青年人才促进会
2013年 上海市药学科技一等奖（排名第四）
1.基金委面上项目，免疫检查点靶向纳米载药系统用于转移性肿瘤免疫协同治疗的研究（51873228）；
2.基金委优秀青年基金，纳米载药系统（31622025）；
3.基金委面上项目，肿瘤微环境自适性纳米载药系统抗乳腺癌转移及其作用机制研究（31671024）；
4.基金委面上项目，双重酸敏感多层阳离子胶束/RNA复合纳米粒的构建及其用于转移性乳腺癌分子靶向治疗的研究（81373359）；
5.科技部“973”课题，生物医用纳米材料的代谢过程及其分析方法研究（2013CB932704）；
6.基金委创新研究群体（参加），基于纳米技术的抗癌药物新型递释系统 （81521005）。
7.中国科学院青促会，药剂学（2014249）；
8.中国科学院药物创新研究院自主部署科研项目，聚乙二醇-奥沙利铂键合前药及其成药性研究（CASIMM0120162002）；
1.Bo Hou#, Lei Zhou#, Hui Wang#, Madiha Saeed, Dangge Wang, Zhiai Xu, Yaping Li, Haijun Yu*. Engineering Stimuli-Activatable Boolean Logic Prodrug Nanoparticles for Combination Cancer Immunotherapy. Adv Mater, 2020. 1907210.
2.Xianli Hu#, Bo Hou#, Zhiai Xu, Madiha Saeed, Zhenmei Gao, Yi Lai, Tong Zhu, Fan Zhang, Wen Zhang, Haijun Yu*. Active Tumor Targeting with Host-Guest Nanoparticles for Combination Immunotherapy of Colorectal Cancer. Adv Sci 2020, 1903332.
3.Ang Gao, Binfan Chen, Jing Gao, Fengqi Zhou, Madiha Saeed, Bo Hou, Yaping Li,* Haijun Yu,* Sheddable Prodrug Vesicles Combating Adaptive Immune Resistance for Improved Photodynamic Immunotherapy of Cancer. Nano Letters. 2020, 20, 353-362.
4.Madiha Saeed, Zhiai Xu, Bruno Geest, Huixiong Xu, Haijun Yu*, Molecular imaging for cancer immunotherapy: Seeing is believing. Bioconjugate Chemistry. 2020, DOI:10.1021/acs.bioconjchem.9b00851.
5.Dangge Wang, Tingting Wang, Haijun Yu,* Bing Feng, Lei Zhou, Fangyuan Zhou, Bo Hou, Hanwu Zhang, Min Luo, Yaping Li*. Engineering nanoparticles to locally activate T cells in the tumor microenvironment. Science Immunology 2019, 4, aau6584.
6.Madiha Saeed, Jing Gao, Yang Shi, Twan Lammers, Haijun Yu*. Engineering Nanoparticles to Reprogram the Tumor Immune Microenvironment for Improved Cancer Immunotherapy. Theranostics 2019; 9: 7981-8000.
7.Bing Feng,# Bo Hou,# Zhiai Xu, Madiha Saeed, Haijun Yu,* Yaping Li* Light-Inducible Nanocargos for Self-Amplified Drug Delivery and Combination Chemoimmunotherapy. Adv Mater, 2019, 1902960.
8.Bing Feng,# Zifei Niu,# Bo Hou,# Lei Zhou, Yaping Li,* Haijun Yu*. Enhancing Triple Negative Breast Cancer Immunotherapy by ICG-Templated Self-Assembly of Paclitaxel Nanoparticles. Adv Funct Mater, 2019. 1906605.
9.Tingting Wang#, Dangge Wang#, Haijun Yu*, Bing Feng, Fangyuan Zhou, Lei Zhou, Hanwu Zhang, Shi Jiao, Yaping Li*. A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors. Nat Commun, 2018,9:1532.
10.Fangyuan Zhou,# Bing Feng,# Haijun Yu,* Dangge Wang, Tingting Wang, Yuting Ma, Siling Wang, Yaping Li*, Tumor Microenvironment-Activatable Prodrug Vesicles for Nano-enabled Cancer Immunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade. Adv Mater. 2018, 1805888.
11.Zhihao Zhao#, Weiqi Wang#, Chenxi Li, Yiqiu Zhang, Tianrong Yu, Renfei Wu, Jiayue Zhao, Zhuang Liu, Jian Liu*, Haijun Yu*. Reactive Oxygen Species-Activatable Liposomes (RALP) Regulating Tumor Microenvironment for Photo/Chemo-Dynamic Therapy. Adv Funct Mater, 2019. 1905013.
12.Li Lei, Zhiai Xu*, Xianli Hu, Yi Lai, Jie Xu, Bo Hou, Ya Wang, Haijun Yu*, Yang Tian, Wen Zhang*. Bioinspired Multivalent Peptide Nanotubes for Sialic Acid Targeting and Imaging-Guided Treatment of Metastatic Melanoma. Small. 2019,1900157.
13.Weiqi Wang, Yilan Jin, Zhiai Xu, Xiao Liu, Sadia Z. Bajwa, Waheed S. Khan, Zhiai Xu, Haijun Yu,* Stimuli-activatable nanomedicine for chemodynamic therapy of cancer. WIREs Nanomedicine & Nanobiotechnology. 2019, DOI: 10.1002/wnan.1614.
14.Qiwen Zhu, Madiha Saeed, Rundi Song, Tao Sun, Chen Jiang, Haijun Yu,* Dynamic covalent chemistry-regulated stimuli-activatable drug delivery systems for improved cancer therapy. Chinese Chemical Letters 2019, DOI:10.1016/j.cclet.2019.12.002.
15.Ang Gao, Xianli Hu, Madiha Saeed, Binfan Chen, Yaping Li, Haijun Yu,* Overview and recent advances in liposomal nanoparticle-based cancer immunotherapy. Acta Pharmacologica Sinica 2019, 40, 1129-1137.
16.Haijun Yu*, Rongqin Huang, Yu Nie, Synthetic nucleic acid nanomedicines: a Chinese perspective (Editorial). The Journal of Gene Medicine. 2019, 21, e3111.
17.Weiqi Wang, Madiha Saeed, Yao Zhou, Lili Yang, Dangge Wang, Haijun Yu*, Non-viral gene delivery for cancer immunotherapy. The Journal of Gene Medicine. 2019, 21, e3092.
18.Jing Gao, Wei-qi Wang, Hai-jun Yu*. Acid-activatable Polymeric Drug Delivery Systems for Cancer Therapy. Acta Polymerica Sinica. 2019, 11, 1156-1166.
19.Fangyuan Zhou#, Bing Feng#, Tingting Wang, Dangge Wang, Zhirui Cui, Siling Wang,* Chunyong Ding, Zhiwen Zhang, Jian Liu, Haijun Yu,* and Yaping Li* Theranostic Prodrug Vesicles for Reactive Oxygen Species-Triggered Ultrafast Drug Release and Local-Regional Therapy of Metastatic Triple-Negative Breast Cancer. Adv. Funct. Mater. 2017, 1703674.
20.Tingting Wang, Dangge Wang, Jianping Liu, Bing Feng, Fangyuan Zhou, Hanwu Zhang, Lei Zhou, Qi Yin, Haijun Yu*, Yaping Li*. Acidity-Triggered Ligand-Presenting Nanoparticles To Overcome Sequential Drug Delivery Barriers to Tumors. Nano Letters. 2017, 17, 5429-5436.
21.Fangyuan Zhou#, Bing Feng#, Tingting Wang, Qingshuo Meng, Dangge Wang, Jianfeng Zeng, Zhiwen Zhang, Siling Wang, Haijun Yu*, Yaping Li*. Programmed Multi-Responsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple-Negative Breast Cancer. Adv. Funct. Mater. 2017, 27, 1606530.
22.Qiang Feng#, Jianping Liu#, Xuanyu Li, Jiashu Sun,* Xinghua Shi, Haijun Yu,* Yaping Li, and Xingyu Jiang* One-Step Microfluidic Synthesis of Nanocomplex with Tunable Rigidity and Acid-Switchable Surface Charge for Overcoming Drug Resistance. Small. 2017, 13:1603109.
23.Dangge Wang,# Tingting Wang,# Jianping Liu, Haijun Yu,* Shi Jiao, Bing Feng, Fangyuan Zhou, Yuanlei Fu, Qi Yin, Pengcheng Zhang, Zhiwen Zhang, Zhaocai Zhou, Yaping Li,* Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy. Nano Letters, 2016, 16, 5503-5513.
24.Tingting Wang#, Dangge Wang#, Haijun Yu*, Mingwei Wang, Jianping Liu, Bing Feng, Fangyuan Zhou, Qi Yin, Zhiwen Zhang, Yaping Li* Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/ Chemotherapy of the Drug Resistant Tumor. ACS Nano. 2016, 10, 3496-3508.
25.Fangyuan Zhou#, Bing Feng#, Haijun Yu*, Dangge Wang, Tingting Wang, Jianping Liu, Qingshuo Meng, Siling Wang,*, Pengcheng Zhang, Zhiwen Zhang, Yaping Li*, Cisplatin Prodrug-Conjugated Gold Nanocluster: A Theranostic Platform for Treatment of Metastatic Breast Cancer. Theranostics. 2016, 6, 679-687.
26.Dangge Wang#, Tingting Wang#, Zhiai Xu, Haijun Yu*, Bing Feng, Junying Zhang, Chengyue Guo, Qi Yin, Zhiwen Zhang, Yaping Li* Cooperative Treatment of Metastatic Breast Cancer Using Host-Guest Nanoplatform Loading Docetaxel and siRNA. Small. 2016, 12, 488-498.
27.Haijun Yu*,#, Chengyue Guo#, Xianzhi Chen, Bing Feng, Jianping Liu, Tingting Wang, Dangge Wang, Zhirui Cui, Qi Yin, Zhiwen Zhang, Yaping Li* Triple-Layered pH-Responsive Micelleplexes Loaded with siRNA and Cisplatin Prodrug for NF-Kappa B Targeted Treatment of Metastatic Breast Cancer. Theranostic, 2016, 6, 14-27.
28.Haijun Yu*,#, Zhirui Cui#, Pengcheng Yu#, Chengyue Guo, Bing Feng, Tongying Jiang, Siling Wang, Qi Yin, Dafang Zhong, Xiangliang Yang, Zhiwen Zhang, Yaping Li*. pH and near-infrared light-responsive micelles with hyperthermia-triggered tumor penetration and cytoplasm drug release reverse doxorubicin resistance in breast cancer. Adv Funct Mater 2015, 25, 2489-2500. (Front Cover)
29.Chongsheng Guo#, Haijun Yu#,*, Bing Feng, Weidong Gao, Mei Yan, Zhiwen Zhang, Yaping Li*, Shaoqing Liu*. Highly efficient ablation of metastatic breast cancer using ammonium-tungsten-bronze nanocube as a novel 1064 nm-laser-driven photothermal agent. Biomaterials 2015, 52, 407-416.
30.Dangge Wang, Zhiai Xu, Haijun Yu*, Xianzhi Chen, Bing Feng, Zhirui Cui, Bin Lin，Qi Yin, Zhiwen Zhang, Chunying Chen, Jun Wang, Wen Zhang, Yaping Li*. Treatment of metastatic breast cancer by combination of chemotherapy and photothermal ablation using doxorubicin-loaded DNA wrapped gold nanorods. Biomaterials. 2014, 35, 8374–8384.
